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Fig. 2.

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Fig. 2. Effects of preincubation time on inhibition of CYP1A1 (A–D), CYP1A2 (E–H), and CYP1B1 (I–L) dependent EROD activities by 1PP (A, E, and I), 1EP (B, F, and J), 2-EP (C, G, and K), and 4Pbi (D, H, and L). P450 (50 pmol) was pre-incubated with different concentrations of 1PP, 1EP, 2EP, and 4Pbi in the presence of 1mM NADPH during indicated periods of time, and then the reactions were started by the addition of 5 μM 7-ethoxyresorufin to determine EROD activities. The reactions were monitored at 25°C. Data are taken from Shimada et al. () with modification.
Toxicological Research 2017;33:79~96
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