Toxicological Research : eISSN 2234-2753 / pISSN 1976-8257

Fig. 2.

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Fig. 2. Self-defense mechanisms against genotoxic chemicals. Genotoxic chemicals may be inactivated by metabolic inactivation. When DNA adducts are formed, the adducts may be removed by DNA repair mechanisms. If the adducts remain in DNA, error-free translesion DNA synthesis (TLS) will incorporate correct dNTPs against the lesions, thereby suppressing induction of mutations.
Toxicological Research 2018;34:281~290 https://doi.org/10.5487/TR.2018.34.4.281
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