Toxicological Research : eISSN 2234-2753 / pISSN 1976-8257

Fig. 5.

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Fig. 5. AgNPs induced the changes in the ultrastructural morphology of cytoplasmic organelles. Cells were treated with (A) control, (B–F) AgNPs (6 μg/mL) for 24 hr and processed for TEM. Notes: Representative TEM micrograph of AgNP-treated cells showed (B) nuclear membrane distortion (black arrow) and numerous initial autophagic vacuoles (Avi), (C) internalization of aggregated-AgNPs in cytosolic vesicles (black stars) and swollen lipid droplets (white stars), (D) blebbed nuclei (black arrow) and accumulation of both initial autophagic vacuoles (inset) and degradative autophagic vacuoles (Avd), (E) swollen mitochondria and mitochondrial cristae disappear (double arrows), and (F) dilation of Golgi saccules (white arrow).
Toxicological Research 2019;35:257~270
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