Fig. 3. Effect of SRE on uric acid, xanthine oxidase activity, and creatinine level in PO-insulted mice. Uric acid level in serum and urine was determined (A). Statistical differences were assessed for total level of uric acid. Xanthine oxidase activity was analyzed in the serum using commercial assay kit (Sigma-Aldrich) (B). Serum creatinine level (C) was determined by Hitachi 7180 (Hitachi). Allopurinol (Allo) was used as an XO inhibitor for the liver, and benzbromarone (Benz) was used as an inhibitor for uric acid transporter 1 in renal tubular cells. Values are presented as mean ± SD. *p< 0.05 versus only PO-treated group; PO, potassium oxonate; SRE, water extract of Radix Saposhnikoviae; XO, xanthine oxidase activity.
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