Fig. 4. Effect of SRE administration on the histology of the kidney. At the end of experiment, the histology of the kidney was analyzed after staining with hematoxylin and eosin. (A and A′) untreated control. (B and B′) PO-treated group. SRE was supplemented at a dose of 125 (C and C′), 250 (D and D′), and 500 mg/kg. (E and E′) in PO-treated mice. (F and F′) allopurinol (5 mg/kg) in PO-treated mice. White and black arrows indicate nuclear condensation and hyaline cast, respectively. Original magnifications of upper and lower images are ×100 (upper panel; A-F) and ×400 (lower panel; A′-F′), respectively. PO, potassium oxonate; SRE, water extract of Saposhnikoviae Radix.
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