Fig. 4. Effects of microneedles (MNs) on the protein expression of adipogenic and lipogenic genes in the subcutaneous adipose tissue (SAT) of rats with high-fat diet (HD)-induced obesity. The inguinal skin of the rats were treated with MNs. Representative blot images of protein expressions are shown (A). The protein levels of fatty acid synthase (FASN) (B), sterol regulatory element-binding protein 1c (SREBP-1c) (C), and anti-peroxisome proliferator-activated receptor-γ (PPARG) (D) were determined by western blotting. β-Actin expression in each sample was used as an internal control to normalize expression. The results shown are representative of at least three independent experiments. Data are expressed as mean ± SEMs of protein levels of tissues from ≥ 3 rats/group. *p<0.05 compared with the control group.
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