Substantial Evidences Indicate That Inorganic Arsenic Is a Genotoxic Carcinogen: a Review
Toxicol. Res. 2018;34:311−324
Published online October 15, 2018;
© 2018 Korean Society of Toxicology.

Jinia Sinha Roy, Debmita Chatterjee, Nandana Das and Ashok K. Giri

Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, Kolkata, India
Ashok K. Giri, Molecular Genetics Division, CSIR-Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Jadavpur, Kolkata - 700 032, India
Received: August 12, 2018; Revised: August 24, 2018; Accepted: September 7, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Arsenic is one of the most toxic environmental toxicants. More than 150 million people worldwide are exposed to arsenic through ground water contamination. It is an exclusive human carcinogen. Although the hallmarks of arsenic toxicity are skin lesions and skin cancers, arsenic can also induce cancers in the lung, liver, kidney, urinary bladder, and other internal organs. Arsenic is a non-mutagenic compound but can induce significant cytogenetic damage as measured by chromosomal aberrations, sister chromatid exchanges, and micronuclei formation in human systems. These genotoxic end points are extensively used to predict genotoxic potentials of different environmental chemicals, drugs, pesticides, and insecticides. These cytogenetic end points are also used for evaluating cancer risk. Here, by critically reviewing and analyzing the existing literature, we conclude that inorganic arsenic is a genotoxic carcinogen.
Keywords : Inorganic arsenic, Genotoxicity, Micronucleus, Chromosomal aberrations


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