Mixture Toxicity of Methylisothiazolinone and Propylene Glycol at a Maximum Concentration for Personal Care Products
Toxicol. Res. 2018;34:355−361
Published online October 15, 2018;  https://doi.org/10.5487/TR.2018.34.4.355
© 2018 Korean Society of Toxicology.

Juyoung Park, Handule Lee and Kwangsik Park

College of Pharmacy, Dongduk Women’s University, Seoul, Korea
Kwangsik Park, College of Pharmacy, Dongduk Women’s University, 60, Hwarang-ro, 13-gil, Seongbuk-gu, Seoul 02748, Korea
E-mail: kspark@dongduk.ac.kr
Received: February 28, 2018; Revised: May 15, 2018; Accepted: July 4, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Methylisothiazolinone (MIT) has been used in combination with methylchloroisothiazolinone (CMIT) for cosmetic products such as shampoo, body lotion, and skin care products. The mixture of CMIT/MIT has been found to cause allergic contact dermatitis and is thus no longer permitted for use as a preservative in leave-on cosmetics. However, MIT itself was approved as a stand-alone preservative at a maximum concentration of 100 ppm as the toxicity was derived from CMIT rather than MIT. However, in many countries, allergic skin irritation caused by MIT remains a social concern. In this study, skin irritation was assessed for the presence of MIT, propylene glycol, and their mixture using a 3D human skin model EpiDermTM. Although non-diluted MIT causes serious skin toxicity, skin irritation was not observed at a concentration of 100 ppm, the maximum permissible level for cosmetics and personal care products according to European regulations. Propylene glycol, the most widely used vehicle for MIT, did not cause skin irritation in the 3D skin model. The results are expected to provide information for regulatory policies and guidelines on the use of biocides in consumer products.
Keywords : Methylisothiazolinone, Propylene glycol, Skin irritation, Mixture toxicity


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