Protective Effects of Plathymenia reticulata and Connarus favosus Aqueous Extracts against Cadmium- and Mercury-Induced Toxicities
Toxicological Research 2019;35:25−35
Published online January 15, 2019;
© 2019 Korean Society of Toxicology.

Kewin Gombeau1,2, Ricardo Bezerra de Oliveira3, Sandra Layse Ferreira Sarrazin3, Rosa Helena Veras Mourão3 and Jean-Paul Bourdineaud1,4

1University of Bordeaux, CNRS, UMR 5805, EPOC, Arcachon Marine Station, 33120 Arcachon, France, 2Present address: University of Bordeaux, CNRS, UMR5095 CNRS, Institute for Cellular Biochemistry and Genetics, 1 rue Camille Saint Saëns, CS 61390, 33077 Bordeaux cedex, France, 3Federal University of Western Pará - UFOPA, PPGRNA, LABBEX, Tapajós Campus, Rua Vera Paz s/n, Bairro Salé, CEP, 68040-050, Caranazal, 88040-060 Santarém, Pará, Brazil , 4Present address: University of Bordeaux, CNRS, UMR MFP 5234, European Institute of Chemistry and Biology, 2 rue Robert Escarpit, 33607 Pessac, France
Jean-Paul Bourdineaud, University of Bordeaux, CNRS, UMR MFP 5234, European Institute of Chemistry and Biology, 2 rue Robert Escarpit, 33607 Pessac, France,
Received: May 16, 2018; Revised: June 21, 2018; Accepted: July 20, 2018
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The extracts of Plathymenia reticulata and Connarus favosus are widely used in the folk medicine. The potential protective effects of these extracts have been evaluated against cadmium in the yeast Saccharomyces cerevisiae, and against mercurial contamination in zebrafish Danio rerio. In yeast, both extracts efficiently protected the Δycf1 mutant strain exposed to cadmium chloride restoring the growth, the expression of stress-response genes and decreasing the level of oxidative stress. In zebrafish, the supplementation of methylmercury-contaminated diet with both plant extracts similarly protected fish through the suppression of the methylmercury-induced lipid peroxidation, decrease of acetylcholinesterase activity, and restoring the expression levels of stress-response genes. This study particularly demonstrates the protective potential of both aqueous extracts against methylmercury, and could represent an interesting alternative for the Amazonian fish-eating communities to cope with the impact of chronic exposure to contaminated diets.
Keywords : Plant extract, Methylmercury, Cadmium, Saccharomyces cerevisiae, Danio rerio, Oxidative stress


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Funding Information
  • Institut National des Sciences de l'Univers, Centre National de la Recherche Scientifique
  • Fundação Amazônia Paraense de Amparo à Pesquisa
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
      88881.030.472, 2013-01, 88881.030.467, 2013-01