Risk Assessment of Triclosan, a Cosmetic Preservative
Toxicol. Res. 2019;35:137−154
Published online April 15, 2019;  https://doi.org/10.5487/TR.2019.35.2.137
© 2019 Korean Society of Toxicology.

Jung Dae Lee1, Joo Young Lee2, Seung Jun Kwack3, Chan Young Shin4, Hyun-Jun Jang5, Hyang Yeon Kim5, Min Kook Kim1, Dong-Wan Seo5, Byung-Mu Lee1 and Kyu-Bong Kim5

1College of Pharmacy, Sungkyunkwan University, Suwon, Korea, 2College of Pharmacy, The Catholic University of Korea, Bucheon, Korea, 3Department of Bio Health Science, Changwon National University, Changwan, Korea, 4Department of Neuroscience, School of Medicine and Center for Neuroscience Research, Konkuk University, Seoul, Korea, 5College of Pharmacy, Dankook University, Cheonan, Korea
Kyu-Bong Kim, Department of Pharmacy, College of Pharmacy, Dankook University, 119 Dandae-ro, Cheonan, Chungnam 31116, Korea
E-mail: kyubong@dankook.ac.kr
Received: February 21, 2019; Revised: March 8, 2019; Accepted: March 10, 2019
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Triclosan (TCS) is an antimicrobial compound used in consumer products. The purpose of current study was to examine toxicology and risk assessment of TCS based on available data. Acute toxicities of oral, transdermal and inhalation routes were low, and phototoxicity and neurotoxicity were not observed. Topical treatment of TCS to animal caused mild irritation. TCS did not induce reproductive and developmental toxicity in rodents. In addition, genotoxicity was not considered based on in vitro and in vivo tests of TCS. It is not classified as a carcinogen in international authorities such as International Agency for Research on Cancer (IARC). No-observed-adverseeffect level (NOAEL) was determined 12 mg/kg bw/day for TCS, based on haematoxicity and reduction of absolute and relative spleen weights in a 104-week oral toxicity study in rats. Percutaneous absorption rate was set as 14%, which was human skin absorption study reported by National Industrial Chemicals Notification and Assessment Scheme (NICNAS) (2009). The systemic exposure dosage (SED) of TCS has been derived by two scenarios depending on the cosmetics usage of Koreans. The first scenario is the combined use of representative cosmetics and oral care products. The second scenario is the combined use of rinse-off products of cleansing, deodorants, coloring products, and oral care products. SEDs have been calculated as 0.14337 mg/kg bw/day for the first scenario and 0.04733 mg/kg bw/day for the second scenario. As a result, margin of safety (MOS) for the first and second scenarios was estimated to 84 and 253.5, respectively. Based on these results, exposure of TCS contained in rinse-off products, deodorants, and coloring products would not pose a significant health risk when it is used up to 0.3%.
Keywords : Triclosan, Cosmetic ingredients, Risk assessment, Rinse-off products


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